Nasopharyngeal carcinoma perfusion MRI

Nasopharyngeal carcinoma in situ in nasopharyngeal carcinoma.

AIMS To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS as well as for the histological assessment of the subtype of CIS. RESULTS ...

Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. The annual incidence of NPC in the UK is 0.3 per million at age 0-14 years, and 1 to 2 per million at age 15-19 years. Incidence is higher in the Chinese and Tunisian populations. Although rare, NPC accounts for about one third of childhood nasopharyngeal neoplasms. Three...

Perfusion Based Functional MRI

1 Perfusion MRI

Broadly speaking, MR imaging techniques can be divided into two groups: those that use extrinsic contrast agents and those that do not. Contrast-enhanced methods for imaging angiogenesis: • Dynamic contrast-enhanced (DCE) MRI using low molecular weight agents (<1,000 Daltons) that rapidly diffuse in the extracellular fluid space (ECF agents) • DCE-MRI using large-molecular agents (>30,000 Dalto...

MicroRNAs in nasopharyngeal carcinoma

It is becoming increasingly evident that aberrantly expressed microRNAs (miRNAs) are responsible for a number of disease processes, including cancer initiation and progression. miRNAs have been implicated as key players in numerous neoplasms, including nasopharyngeal carcinoma (NPC). Functionally, deregulation of miRNAs that act either as tumour suppressors or oncogenes results in numerous canc...